Semaglutide

Current options: Compounded Sublingual Semaglutide

No longer available: Compounded Semaglutide/Tirzepatide for injection

Trade Name Availability: (available by special order only, prepayment is required): Wegovy®, Ozempic®, Rybelsus®, Mounjaro®, Zepbound®

Compounded Sublingual Semaglutide

Instructions prior to use:

1. Perform normal oral hygiene routine.
   1. It is strongly suggested that flossing/water-flossing occurs before use.
2. After oral hygiene, rinse mouth with warm water
3. Best if used in morning, to help with appetite suppression throughout the day.

Instructions for use:

1. Hold dose under the tongue for as long as possible.
   1. Ideally for a Minimum of 5 minutes.
      1. Strongly suggested to hold in mouth for 10 minutes if possible
      2. Might be easiest to utilize while showering.
2. No food or drink for as long as you can continue to taste the mint flavor from the medication.
   1. This is likely to be at least 1 hour.
3. Repeat daily, or as directed by prescriber.

This is a compounded medication. FDA does not review compounded medications for safety or efficacy. SubMagna® HMW is a registered trademark of Kingdom Licensing. The following guide to compounded sublingual semaglutide dosing is based on the Prescribing Information (PI) for commercially available injectable semaglutide, which indicates approximately 89% systemic absorption via subcutaneous administration. For the purposes of this guide, it is ESTIMATED that compounded sublingual administration using SubMagna® HMW achieves 10% systemic absorption.